Patients who have a pregnancy of unknown location (PUL) and request medication abortion (MA) should receive abortion care without delay, provided that they have no clinical symptoms of ectopic pregnancy (EP). Failure to identify a definite intrauterine pregnancy should not delay MA[6].

If the serum βhCG is > 2000 IU / L and no intrauterine gestational sac is visualized on ultrasound[6]:

• Further investigation is required.

In the absence of EP risk factors, if βhCG is ≤ 2000 IU / L or a likely gestational sac is present without a yolk sac or fetal pole[6]:

• Patients with PUL can receive MA.
• When PUL patients receive MA, they should be informed of the risks and symptoms of EP, and who to contact in case of emergency.
• Follow-up βhCG within 7 days is recommended for PUL patients. A decrease of 50% at 3 days after mifepristone administration (or 24-48 hours after misoprostol) or 80% between 7 and 14 days after MIFE / MISO administration is expected; otherwise, EP should be ruled out.